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ea0029oc1.5 | Pituitary Clinical I | ICEECE2012

Initial hypothalamic involvement is the major risk factor for impaired prognosis and quality of life in childhood craniopharyngioma regardless of chosen treatment strategies: results of KRANIOPHARYNGEOM 2000

Muller H. , Gebhardt U. , Warmuth-Metz M. , Kortmann R. , Faldum A. , Pietsch T. , Gabriele C. , Sorensen N.

Hypothalamic obesity has major impact on prognosis and quality of life (QoL) in childhood craniopharyngioma (CP). The pathogenic relevance of initial hypothalamic involvement versus treatment-related hypothalamic lesions is a matter of controversy.One hundred and twenty patients were recruited prospectively during 2001 and 2007 and evaluated after 3 years of follow-up. Body mass index (BMI) and QoL at diagnosis and 36 mo after diagnosis were analyzed bas...

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ea0029p1307 | Paediatric endocrinology | ICEECE2012

Randomized multicenter trial on patients with childhood craniopharyngioma (KRANIOPHARYNGEOM 2007): update after 49 months of recruitment

Muller H. , Gebhardt U. , Kortmann R. , Warmuth-Metz M. , Faldum A. , Pietsch T. , Sorensen N. , Calaminus G.

Despite high survival rates (92%) in patients with childhood craniopharyngioma (CP), quality of life (QoL) is frequently impaired due to sequelae such as severe obesity resulting from hypothalamic involvement of CP. Based on the results of the multicenter prospective study KRANIOPHARYNGEOM 2000 radical surgery is no appropriate treatment strategy in patients with hypothalamic involvement. Furthermore, tumour progression/relapses are frequent early events in CP patients. The an...

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Endocrine Abstracts

Initial hypothalamic involvement is the major risk factor for impaired prognosis and quality of life in childhood craniopharyngioma regardless of chosen treatment strategies: results of KRANIOPHARYNGEOM 2000

Randomized multicenter trial on patients with childhood craniopharyngioma (KRANIOPHARYNGEOM 2007): update after 49 months of recruitment

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